消炎痛治疗急性化脓性腹膜炎的研究

Experimental study on treatment for a-cute purulent peritonitis with indomethacin

建立厌氧菌及需氧菌混合感染的大鼠急性化脓性腹膜炎模型，并观察消炎痛对其死亡率、腹腔脓肿形成率、腹腔脓肿大小及腹腔粘连率的影响；还观察了其单核细胞生成ＰＧＥ＿２能力的变化。结果发现，消炎痛可降低脓肿形成率、减少脓肿体积、降低粘连形成率并抑制ＰＧＥ＿２的生成，统计学差异有显著性意义（Ｐ＜０．０５或Ｐ＜０．０１）；但消炎痛对死亡率的影响不显著（Ｐ＞０．０５），死亡率仅有下降的趋势。

Tianjin Institute of Acute Abdomi-nal Disease, Tianjin 300100.In this study,acute purulent peritonitisrat model wasestablished with aerobic andanaerobic bacteria infection. The effect of in-domethacin on its mortality,the rate of intra-abdominal abscess formation,the size of ob-scessesand the rate of peritoneal adhesionwere observed.The results showed that in-domethacin could reduce the rate of abscessformation,decrease the size of abscesses andreduce the rate of adhesion. Indomethacin could inhibit the production of PGE_2 by mono-cyte, but the mortality was not decreased sig-nificantly.