摘要
用ABC-ELISA法对50例重症肌无力(MG)病人血清中抗乙酰胆碱受体抗体(AchRab)和抗突触前膜抗体(PrMab)进行检测。结果发现:①MG患者抗体总阳性37例(阳性率74%),其中AchRab阳性33例(66%),PrMab29例(58%),二者均显示重症患者阳性率高于轻症。②血清中两种抗体滴度重症患者均明显高于轻症,胸腺肿瘤AchRab滴度明显高于胸腺增生病例,抗体滴度与胸腺病理关系呈肿瘤>萎缩或正常>增生。③AchRab和PrMab高度相关。结果表明AchRab与MG病情轻重和胸腺病理有一定关系,可用于MG的病情监测,PrMab同样可以作为MG的一项免疫学诊断指标,有重要的临床应用价值。
The acetylcholine receptor antibody(AchR ab ) and presynaptic membrane anti-body(PrM ab ) in sera were measured from 50cases with myasthenia gravis(MG)by usingthe method of ABC-ELISA. the result showed that(1) AchR ab were positive in 33 cases(66%)of MG patient,PrM ab positive in 29cases(58%),with the total(both or one ofthem ) positive rate of 74%(37 cases). Thepositive rate in severe cases was higher thanthat in mild cases;(2)the antibody level insera was much higher in severe cases than inmild cases and the AchR ab level in thymomawas higher than that of hyperplasia.The anti-body levels related to thymus physiologyshowed an order of thymoma>atrophy ornormal > hyperplasia.(3)A great relevancewas found between AchR ab and PrM ab. It is suggested that AchR ab bear some relationwith the severity of MG and thymus physiolo-gy and that it could be used in monitoringMG. PrM ab is also valuable as an diagnosticindex for immunity.
出处
《中华实验外科杂志》
CSCD
北大核心
1995年第6期332-333,共2页
Chinese Journal of Experimental Surgery
关键词
重症肌无力
乙酰胆碱
受体
抗体
抗突触前膜
myasthenia gravis
acetyl-choline receptor antibody
presynaptic mem-brane antibody