硒、钙、锗对大肠癌的阻抑作用

Interference of selenium germanium and calcium incarcinogenesls of colon cancer

作者对１２０只Ｗｉｓｔａｒ大鼠以二甲肼（ＤＭＨ）诱发大肠癌。动物随机分为８组予以不同饮食，处死后尸解，观察检查各脏器出现肿瘤情况，包括肿瘤性质、数目、部位、组织学类型、以及超微结构改变，并进行统计学处理、比较。结果表明高脂饮食对ＤＭＨ的致癌性具有明显的促进作用。硒和钙则有明显阻抑ＤＭＨ的致癌作用，而且硒对高脂饮食的促癌性也有明显的阻抑作用，锗则未见对ＤＭＨ的致癌性有任何阻抑作用。

AbstractWe studied DMH induced colon cancer in 120 wis-tar rats ,which were divided into 8 groups based on dif-ferent diets. They were killed and autopsied on 4weeks after the last injection of DMH.The tumors invarious organs including its characteristics,number,site, histological types and ultrastructural changeswere observed. The results showed that high fat diethas a significant effect on DMH induced colon cancer.Selenium and calcium can inmibit the effect of DMNand decrease the incidence of colon cancer.Sdeniumcan also interfere the effect of high fat diet but germa-nium has no effect on colon carcinogenesis。