肝硬化患者血清胃泌素水平与溃疡病发生的关系

The level of serum gastrin and ulceration in cirrhoticpatients with portal hypertention

肝硬化门脉高压症患者胃、十二指肠溃疡发病率明显增加，其机理不明。作者通过对２４例肝硬化患者空腹血清胃泌素，自由门脉压及其中１３例基础胃酸分泌量（ＢＡＯ）的观察，发现７１％的患者存在高胃泌素血症，均呈低胃酸状态；且门脉压愈高，胃酸愈低。作者认为肝硬化患者胃、十二指肠溃疡高发的主要原因为门脉高压致胃、十二指肠粘膜损害，胃泌素促胃酸分泌作用不明显。

AbstractAhigher incidence of gastric and duodenum ulcerwas well recognized in patients with liver cirrhosis.but the mechanism has not been fully identified. In this.study,serum gastrin,free portal pressure(FPP)weremeasured in 24 consecutively admitted cirrhotic portalhypertensive patients,and preoperative basic acid out-put(BAO)was measured in 13 randomized patients.Among the 24 patients,concomitant duodenal ulcerswere found in 3 by both gastroduodenoscopy and bari-um series,and gastritits was found in all patients.Itwas found that most patients(71/)with liver clrrho-sis have a elevated level in serum gsstrin,whereasBAO is lower than normal in all patients,and the higher the FPP. the lower the BAO is. We believe thatthe congestive gastroduodenal mucosal lesion was un-derlying the ulceration most often seen in patients withportal hypertension.