男性乳腺发育症性激素变化与雌激素受体状态的临床研究

Clinical studies on changes of s exual hormones and es-trogen receptor in patients with gynecomastia

作者采用放射免疫法及亲和酶标法测定了４６例男世乳腺发育症血清睾丸酮（Ｔ）、雌二醇（Ｅ＿２）水平和组织标本的雌激素受体（ＥＲ）状况。结果表明Ｅ＿２升高，Ｅ＿２／Ｔ比值改变作为该症发病的整体因素作用肯定，而ＥＲ阳性表达则是其发病的重要局部因素。Ｅ＿２和ＥＲ在男性乳腺发育症的发生、发展中起着协同作用，可导致导管上皮增生，能否进一步发生癌变亦值得警惕。

AbstractLevels of serum testosterone(T),estradiol(E_2),and estrogen receptor(ER)in the tissue were detectedby radioimmunassay and immunohistochemical method(ABC technique)in 46 patients with gynecomastia.The results showed that rise of E_2andE_2/T is a whole-body etiologic factor of hypertrophy of male breast,and the positive rate of ER is an important local etio-logic factor of gynecomastia. E_2 and ER have aosyner-gism effect on onset and development of gynecomastiaand cause the ductal cell hyperplasia of male breast.Itshould be alerted whether it can cause male breast can-Cer.