甲氰咪胍对门静脉高压症肝血流状态影响的声象观察

Computed sonography observation on the effects ofcimetidine on the liver blood flow in cirrhotic patientswith portal hypertension

作者应用电脑声象仪对２０例肝硬变门静脉高压症患者静脉输注组织胺＿２，受体拮抗剂甲氰咪胍０．４ｇ后肝脏血流状态变化情况进行了观察。结果显示，在应用甲氰咪胍后，门静脉截面积增加１６．８％±１７．３％，平均最大血流速率增６０３３．１９％±３７．０７％，门静脉最大流量之计算值增加５３．２／±５２．３％；三支肝静脉截面积平均增加４０．２％±８１．３％，血流速率增加２６．２９±３９．０３％，肝静脉血流量计算值增加６０．２％±６３．６％（Ｐ均＜０．０１）。提示甲氰咪胍对门静脉高压症患者肝血管床有明显扩张作用，从而降低了门静脉血流阻力。

AbstractThe effects of cimetidine on the hepatic and portalvein blood flow were investigated in 20 cirrhotic pa-tients with portal hypertension by computed sonogra-phy. Cimetidine given intravenously at a dose of 0.4gsignificantly increased the hepatic vein blood flow(60.2%±63.6%,P<0.01),at the same time its cal-culated cross section area increased by 40.2%±81.3%(P<0.01).The portal vein blood flow increased by53.2%±52.3%(P<0.01).While its cross sectionarea was 16.8%±17.3%(P<0.01 ). These resultsshowed that the histamine H_2-receptor antagonist cime-tidine may dilate liver vascular bed and reduce portalblood flow resistance in cirrhotic patients with portalhypertension.