109HH人工腱在兔体内腱化过程的电镜观察

Ultrastructural observation of tendonization of artifi-cial tendon 109HH in rabbit

取新西兰兔１０只，分为术后２、６、１２、２８周实验组及正常对照组。实验组行双侧跟腱手术，将１０９ＨＨ人工腱接入断腱的两端，术后按计划如期用电镜观察其超微结构变化。结果发现２～６周成纤维细胞增殖，胞质内有丰富核糖体和粗面内质网。这表明人工腱植入体内早期能刺激成纤维细胞增生，合成胶原蛋白旺盛，是制造胶原纤维最多时期。１２～２８周成纤维细胞数量逐渐减少，合盛胶原蛋白功能由盛转衰，最后成纤维细胞变成功能不活跃的腱细胞。新腱在逐步形成的同时，人工腱在体内也不断的被降解、吸收，１２周后完全消失。新生腱经过聚合、改建之后，健纤维变粗，在结构与功能上均达到正常胜水平。

AbstractTen New Zealand rabbits were divided into 5groups at random. Calcaneal tendons were cut bilater-ally,then atificial tendon 109NH was used to connectthe two ends of the cut tendon. Ultrastructuralchanges of control group and experimental groups at 2,6, 12,28 weeks after section were observed.The re-sults showed that fibroblast proliferated and a lot of ri-bosome and RER appeared in plasm during 2～6weeks,indicating artificial tendon caused fibroblastproliferation. During this period, fibroblast over syn-thesized collagenous protein and the synthesis of col-lagenous fibers peaked. During 12～28 weeks,thenumber of fibroblasts and the synthesis of collagenousprotein decreased.Finally,fibroblasts became inactivetendon cells.With the formation of new tendons,theartificiaI tendens were degradated and absorbed ,anddisappeared after 12 weeks. The new tendon fibers be-came thicker and had hte correct direction through re-construction. The structure and function of newtendons could be restored to be consistent withnormalvalues.