遗传过敏性皮炎患者血清IL-4水平与IgE的关系

STUDY ON THE RELATIONSHIP BETWEEN SERUM IL-4 AND IgE IN PATIENTS WITH ATOPIC DERMATITIS

采用酶联免疫技术检测21例遗传过敏性皮炎(AD)患者血清白细胞介素4(IL—4)及IgE水平。实验结果发现,AD患者血清IL—4水平比正常人显著增高(P<0.02),并且与IgE密切相关(r=0.853,P<0.001)。说明AD的发病与IL—4产生失调,从而导致B细胞合成IgE增加有关。人IL—4酶联免疫检测具有敏感、特异、简便、快速及结果可靠等特点。

An ELISA procedure for the quantitative determination of serum IL-4 and IgE levels were done in 21 patients with atopic dermatitis (AD). The results showed that serum IL-4 levels were significantly(P<0. 02) higher in AD pa tients than that of control. The serum IL-4 was closely related to IgE(r = 0. 853,P<0. 001). The imbalance of 1L- 4 production played an important role in the pathogenesis of AD,which may contribute to increased IgE synthesis by B cells. It suggests that ELISA for human IL-4 is characteristic of sensitivity .specificity .simplicity,rapid and reliability for the results.