IgA肾病小管间质病理改变的意义

Significance of Tubulointerstial Lesions in IgA Nephropathy

采用微机图像处理系统对５２例ＩｇＡ肾病的小管间质病理形态、间质淋巴细胞亚群和单核细胞分布进行定量分析。结果：肾活检和随访中的血清肌酐浓度与皮质间质面积密度、间质胶原面积密度、小管毛细血管距离、间质ＣＤ、ＣＤ、ＣＤ及单核细胞数密度呈显著正相关，与近曲小管上皮细胞面积密度、球后毛细血管数和面积密度呈显著负相关；小管间质病变程度与病人肾活检时的年龄、病程、平均动脉压、临床表现、节段性或球性肾小球硬化率显著相关；间质单核细胞、ＣＤ和ＣＤ细胞密度显著高于１２例移植供肾组织；伴新月体者间质ＣＤ和单核细胞密度显著高于无新月体者。

Fifty-two patients with biopsy-proven IgA nephropathy were involved in this computerinterstial volume and collagen area density, the diffusion distances between tubuli and Postglomerular capillaries,CD and CD cells as well as monocytes density in the interstitium; but negatively correlated with proximal tubuli epithelial cells area density. postglomerular capillaries area and number density.manifestations, and segmental or globular glomerulosclerosis.Monocytes,CD cells CD cells density in the interstitium of the patients were much more than those of kidney transplant donors,there were far more interstitial CD cells and monocytes denisity in crescentic biopsies than noncrescentic ones.