大鼠急性坏死性胰腺炎合并肾损害及前列环素的保护作用

RENAL DAMAGE FOLLOWING ACUTE NECROTIZING PANCREATITIS IN RATS AND THE PROTECTIVE EFFECT OF PROSTACYCLIN

制作大鼠急性坏死性胰腺炎（ＡＮＰ）模型，观察肾组织学、肾功能的变化及前列环素（ＰＧＩ２）的影响。结果发现，ＡＮＰ模型制作后４８小时，肾组织出现严重的损害，肾功能明显下降，肾静脉血６－酮－ｐＧＦ１α／ＴＸＢ２比值、肾血流量及肾组织灌流量均明显下降。给予外源性ｐＧＩ２能明显增加６－酮－ｐＧＦ１α／ＶＴＸＢ２比值，增加肾血流量及肾组织灌流量，减轻肾组织学改变，改善肾功能。

A rat model of acute necrotizing pancreatitis was made, its renal histologic and renalfunctional changes also, the influence of prostacyclin (PGI2)were observed. 48 hours afteranimal model had been made there emerged severe renal histological damage, renal functionsignificantly deteriorated,the ratio of 6-keto-pGF1α to TXB2 in blood of renal vein, the renalblood flow and renal tissue perfusion all were diminished remarkably. When exogenous PGI2was given,the above parameters were all remarkably incrased and renal function muchimproved exogenous PGI2 can protect against such damage。