白细胞介素－2激活的肿瘤浸润淋巴细胞治疗晚期胃癌的临床观察

CLINIAL OBSERVATON ON THE TREATMENT OF ADVANCED STOMACH NEOPLASMS WITH IL-2 ACTIVATED TIL

对１３例晚期胃癌患者进行肿瘤浸润淋巴细胞（ＴＩＬ）免疫治疗。研究结果表明，ＴＩＬ治疗晚期胃癌，可使患者瘤体缩小，生存期延长，１年以上生存率为５３．８５％；疼痛减轻（８５％）；体重增加（７６％），与自身及对照组相比，差异有显著性（Ｐ＜０．０５）。通过ＯＫＴ４／ＯＫＴ８比值，ＳＩＬ－２Ｒ、ＮＫＣ、ＢＣＧ免疫功能的检测比较，表明ＴＩＬ治疗晚期胃癌患者可调节机体免疫平衡，促进其免疫功能的提高，增强机体的抗癌能力，达到减轻痛苦、延长生命的目的。本研究认为，在晚期胃癌患者的综合治疗中，ＴＩＬ免疫疗法可作为重要治疗方法之一。

3 cases of advanced stomach neoplasms were treated with TIL immunotherapy. Theresults showed that the treatment of advanced stomach neoplasms with TIL could lessen thetumor mass, prolong the patients’ survival time(the rate of survival period over one year was53.85%), alleviate pain(85%)and raise the body weight(76%). There were great differencecompared with selves and control groups(P<0.05). The resuIts of OKT4/OKT8, sIL-2R, NK,BCG suggested that the treatment of advanced stomach neoplasms with TIL could modulatethe immunologic homeostasis, promote the development of the immunologic function,enhance the anti-cancer activity of the bodies. TIL immunotherapy could be regarded as oneof the important therapeutic methods in the treatment of advanced stomach neoplasms.