西沙必利治疗反流性食管炎多中心双盲对照临床观察

A DOUBLE-BLIND MLTICENTER TRIAL 0F CISAPRIDE oN REFLUX EXOPHAGITIS

应用双盲多中心研究观察了西沙必利（普瑞博思）和雷尼替丁治疗１００例反流性食管炎的疗效。西沙必利１０ｍｇ，４次／ｄ，雷尼替丁为１５０ｍｇ，２次／ｄ。每２周复诊Ｉ次，４周后复查内镜，如未愈合，８周后再次检查内镜。结果表明，二组患者治疗后症状的总分均明显下降。内镜下反流性食管炎，西沙必利和雷尼替丁治疗的愈合率分别为６２．８％和５０．０％。仅少数病例出现不良反应。本研究表明，西沙必利对治疗反流性食管炎有明显疗效，与雷尼替丁可比。

In a double-blind,randomized,comparative trial of the prokinetic drug cisapride and H2- blocker ranitidine,with refiux symptom score and healing of esophageal lesion wereevaluated in l00 patients with reflux esophagitis confirmed by endoscopy. Cisapride l0mg qid(N=46)or ranitidine,150mg twice daily(N= 54)for 8 weeks.Upon entry,3.4% and 33.3% ineach group had grade l reflux esophagitis,the rest were grade Ⅱ orⅢ.At the end of 4 weeksboth drugs could significantly decrease symptom scores;at the end of 8 weeks, the cumulativehealing rate was 62.8% in cisapride group,and 50.o%in ranitidine group. Only 9.3% and6.8% in each group had grade Ⅱ or gradeⅢ esophagitis (both P< 0.01).No significantadverse effects were seen in cisapride group。 The resuIts indicate that cisapride is comparableto ranitidine in it’s therapeutic effect in reflux esophagitiso.