摘要
羟氨苄青霉素悬液（２５０ｍｇ／ｋｇ）灌胃，可显著预防利血平（５ｍｇ／ｋｇ）腹腔注射诱发的大鼠实验性胃溃疡的发生。羟氨苄青霉素可提高利血平溃疡大鼠腺胃粘膜超氧物化歧化酶（ＳＯＤ）活力，降低粘膜氧自由基代谢产物丙二醛（ＭＤＡ）含量，而对溃疡形成过程中的高胃酸分泌、脑组织和腺胃组织单胺神经递质含量的下降，及粘膜前列环素（ＰＧＩ２）、血栓素Ａ２（ＴＸＡ２）无明显影响。结果提示：预防氧自由基损伤，是羟氨苄青霉素预防大鼠利血平实验性溃疡形成的主要机制。
Amoxicillin(250mg/kg,intragastrically) could significantly prevent
reserpine(5mg/kgintraperitoneally)induced ulceration in Hp(─)
rats.Amoxicillin(150mg/kg,intragastically)does not influence reserpine(5mg/kg intraperitoneally)
induced acid secretion in pylorus-lig-agated rats and had no effect on gastric mucosal PGI2 and
TXA2 metabolism(by detectingmucosal 6-keto-PGF1α and TXB2,by RIA).Amoxicillin did not
influence reserpine-induceddepletion of noradrenaline,dopamine and 5-hydroxytrptamine in
brain and gastric mucosa.we found that amoxicillin could elevate SOD activity and lower
malondialdehyde(MAD,anindicator of oxygen free radical)concentration in gastric mucosa in
reserpine injected rats.Inconclusion, amoxicillin can protect rats from reserpine-induced gastric
ulceration mainlythrough prevention of oxygen radical mediated damage. This study suggests
that amoxicillinmay heal peptic ulcer by clearing Hp as well as preventing oxygen free
radical-mediateddamage.
出处
《中华消化杂志》
CAS
CSCD
北大核心
1995年第5期279-281,共3页
Chinese Journal of Digestion
