细胞性纤维连接蛋白在肾母细胞瘤中表达的研究

The Research of Fibronectin Expression in Children with Wilms' Tumor

用过氧化物酶－抗过氧化物酶技术光镜下观察细胞性纤维连接蛋白（ＣＦＮ）在６３例肾母细胞瘤组织中表达强度与分布，探讨其与组织类型、预后之间的关系。结果，ＣＦＮ表达与瘤组织类型有关：上皮型，ＣＦＮ分布以肾小管样结构周围为主，而且表达强度高；间质型，ＣＦＮ多分布在细胞内，两者差异有显著意义（Ｐ＜０．０５）。ＣＦＮ表达情况与肿瘤的临床分期无关。当ＣＦＮ分布在细胞周围，表达强度高者，预后好，生存５年以上者多。

By the method of PAP. the expression and distribution of cell fibronectin (CPN) in 63 children with Wilms'tumor were observed under light microscope. The results showed that the expression of CFN was correlated with the histological type of the tumor. In epithelial type, CFN distributed around the cell and had a high expression intensity. In stromal type, CFN distributed inside the cell (P <0.05) . There was no relationship between the expression of CFN and the clinical staging. When CFN distributed around the cell and showed a high expression intensity,a better prognosis was expected. The expression of CFN may act as an index to predict the prognosis of Wilms' tumor.