小儿晚期恶性肿瘤延期和二次手术的指征与时机

Significance of the Chromosome Aberration in Children With Malignant Tumor

小儿晚期恶性肿瘤延期和二次手术的指征与时机高解春小儿恶性肿瘤由于生长迅速，早期转移和延误诊治，确诊时已为Ⅲ、Ⅳ期晚期肿瘤者可达５０％～７０％。对于此类晚期患儿，争取原发肿瘤的完整切除和转移灶的满意控制是提高生存率的关键所在。近年，国内外文献均报道应用...

The chromosome aberration in 10 children with malignant tumor was observed and compared with normal children.These patients commonly had chromosome fragmentation.gap or dicentric chromosome.Six of them had chromosome deletion at distal end.The chromosome aberration rate in children with malignant tumor(2.13%)was remarkably higher than that in normal children(0.5%).The significance of chromosome aberration on tumor pathogenesis,gene mutation and genetic research is discussed.