不稳定性心绞痛患者的高胰岛素血症

Hyperinsulinemia in patients with unstable angina pectoris

检测冠心病不稳定性心绞痛２４例，稳定性心绞痛２９例，对照组３０例糖耐量前后血糖、胰岛素（Ｂ）、Ｃ肽（ＣＰ）的变化。结果不稳定性心绞痛组和稳定性心绞痛组空腹和服糖后的ＩＳ、ＣＰ均明显升高，前组与后组相比，显示更高的ＴＳ、ＣＰ浓度（Ｐ＜０．０５～０．００１）。提示冠心病的高胰岛素血症与其临床症状的严重程度相关，而高胰岛素血症对神经体液的影响可能会导致心绞痛的恶化。

Abstract Blood glucose (BG),insulin (IS) and C-peptide (CP) levels during OGTT were measured in 24 coronary heart disease (CHD) patients with unstable angina pectoris (UA), 29 CHD patients with stable angina pectoris (SA) and 30 control subiects.The results showed that serum IS,CP levelsafter fasting and during oral glucose load appeared significantly increased in CHD patients compared with control group.The UA patients showed higher IS and CP concentration compared with SA (P<0.05-0.001).The results indicate that hyperinsulinernia was related with the severity of symptoms in CHD patients.The neurohumoral effects of hyperinsulinemia may be the cause of the exaggerated angina pectoris.