减重对血压、血脂、血糖及血尿酸的影响

Effect of weight loss on blood pressure,serum lipids,serum uric acid and plasma glucose

分析４３例超重者（体重指数＞２５ｋｇ／ｍ２）经８周减重后血压、血脂、血糖及尿酸的变化情况表明：收缩压和舒张压分别平均下降０．４４和０．４３ｋＰａ（３．３和３．２ｍｍＨｇ）（Ｐ值均＜０．０５）。血清总胆固醇、甘油三酯分别平均下降０．３３８ｍｍｏｌ／Ｌ和０．４０７ｍｍｏｌ／Ｌ（Ｐ值均＜０．０１）；低密度脂蛋白胆固醇平均下降０．１３８ｍｍｏｌ／Ｌ但未达统计学显著水平；高密度脂蛋白胆固醇和低密度脂蛋白胆固醇比值未见明显变化。血清尿酸平均下降４１．６５μｍｏｌ／Ｌ（约１３％，Ｐ＜０．００１）。血糖无明显变化。说明本组超重者不仅体重得到了控制，而且血压、血脂模式和血尿酸等均发生了有利于心血管病预防的转变。

Abstract Objective:To observe the effect of weight loss program on blood pressure,serum lipids,serum uric acid and plasma glucose.Subjects:43 overweight (BMI> 25 kg/m2) men and women.Methods:Before and after 8 weeks dietary adjustment for weight foss, a 12-hour fasting sample was drawn and blood pressure recorded. Serum lipids (including TC, TG and HDL-C),glucose and uric acid were measured then.Results: On average, SBP and DBP decreased by 3.3and 3.2 mmHg respectively (both P<0. 053 ), TC and TG by 13. 0 and 36. 0 mg/dl respectively (both P<0. 01), TC/HDL-C by 0- 3 (P<0.05) , LDL-C decreased by 5. 3 mg/dl but not statisticaly significant;HDL-C, HDL-C/LDL-C ratio and glucose changed insignificantly.Uric acid decreased significantly by 0.7mg/dl (about 13% ) .Conclusion:Weight loss program,based on dietary adjustment,can not only reduce weight,but also make favorable changes in blood pressure,serum lipids profile and uric acid in terms of prevention of cardiovascular diseases.