急性心肌梗塞和不稳定性心绞痛血浆纤维蛋白肽A动态变化的比较

A comparative study of the dynamic changes of fibrinopeptide A in patients with acute myocardial infarction and unstable angina

观察了１２例急性心肌梗塞（ＡＭＩ）和２５例不稳定性心绞痛（ＵＡ）患者血浆纤维蛋白肽Ａ（ＦＰＡ）的动态变化。结果表明：（１）９１．７％的ＡＭＩ患者在发病最初３天血浆ＦＰＡ明显升高，以发病１２小时内升高最为显著，发病后第７天基本恢复正常。（２）６８％的ＵＡ患者在症状期入院的第１天血浆ＦＰＡ明显升高，入院后第３天ＦＰＡ降至正常，其ＦＰＡ升高的幅度和持续时间均小于ＡＭＩ患者。表明ＡＭＩ较ＵＡ患者其病变的冠脉内有更强的促凝的病理因素和更高的血栓形成的发生率。

Abstract Dynamic changes of serum fibrinopeptide A (FPA)were studied in 12 patients with acute myocardial infarction (AMI)and 25 ones with unstable angina (UA).The results showed that FPA values were signfifcantly higher in 11 patients with AMI(91.7%) in first three days after the onset. As the peak FPA level was within 12 h after onset, it may be a signal of hypercoagulable state in early AMI which will lead to coronary thrombosis.FPA level was also elevated in 17 cases with UA(68%), but the peak level in FPA was much lower than those in AMI. So, it is reasonable to say that AMI is more thromboplastic than UA.FPA level decreased to normal on the 7th day after onset of AMI and the third day after UA. It seems rational to suggest anticoagulant therapy at least for a week in AMI and three days in UA.