阿米洛利对缺血心肌的保护作用

The Protective Effects of Na+-H+ Exchange Inhibitor(Amilioride)on Ischemic Myocardiuim

２０例心内直视术病人随机分为对照组（Ⅰ组，ｎ＝１０）和实验组（Ⅱ组，ｎ＝１０）。Ⅰ组采用冷高钾停搏液，Ⅱ组于停搏液中加入阿米洛利（ａｍｉｌｏｒｉｄｅ）。与Ⅰ组相比，Ⅱ组术后心律失常发生率低，自动复跳率和心房颤动转窦率高，血流动力学恢复好，心肌超微结构损伤轻及ＣＰＫ释放量少。提示Ｎａ＋—Ｈ＋交换抑制剂阿米洛利具有明显抗心肌再灌注损伤的作用。

Twenty patients undergoing open heart surgery were randomly divided into control group(n = 10, I) with cold potassium solution(CPS)and amiloride group (n= 10, II) with CPS plus amiloride (0. 5mM).Lower incidence of arrhythmia,higher rate of spontaneous defibrillation and convertion of atrial fibrillation to sinus rhythm,better recovery of hemodynamics ,and less damage of ultrastructure and release of CPK were demonstrated in group II in comparison with group I. It is concluded that Na￣+-H￣+ exchange inhibitor,amiloride,is an effective protective agent for myocardial reperfusion injury.