抗T淋巴细胞单克隆抗体对重型再生障碍性贫血造血祖细胞的影响

THE EFFECT OF MONOCLONAL ANTIHUMAN T-CELLANTIBODY ON HEMOPOIETIC PROGENITOR CELLS OFSEVERE APLASTIC ANEMIA

报告抗Ｔ淋巴细胞单克隆抗体（ＭｃＡｂ－Ｔ）对重型再生障碍性贫血（ＳＡＡ）造血祖细胞的影响。发现经ＭｃＡｂ－Ｔ体外清除（ＳＡＡ）骨髓中的ＣＤ＿３或ＣＤ＿８细胞后，１９例ＳＡＡ中有１０例患者的粒－单核系祖细胞集落及红系祖细胞集落产量明显增多（Ｐ＜０．０１）。提示部分ＳＡＡ的发病与Ｔ淋巴细胞的免疫抑制有关。在体内应用ＭｃＡｂ－Ｔ（抗ＣＤ＿３和抗ＣＤ＿８）治疗后，该１０例患者临床疗效显著，其中基本治愈、缓解共６例，明显进步４例。结果表明，ＭｃＡｂ－Ｔ能特异性地抑制相应的Ｔ淋巴细胞，解除Ｔ淋巴细胞对造血功能的直接或间接抑制作用，从而使ＳＡＡ患者的造血功能得以恢复。

he effect of monoclonal antihuman T-cell antibody(McAb-T) on hemopoietic progenitor cells of 19 patientswith severe aplastic anemia (SAA) was observed. Thecolony yields of CFU-GM and CFU-E in 10 cases wereincreased markedly (P<0.01) after the CD or CDcell in the bone marrow were cleared out by McAb-T .After McAb-T (anti-CD_3 and anti-CD_8) therapy these10 patients gained marked clinical improvements , with 6cases being cured or rernitted.