34例成人急性白血病患者脑脊液中可溶性白细胞介素2受体测定的临床意义

THE VALUE OF SOLUBLE INTERLEUKINZ RECEPTORIN CEREBROSPINAL FLUID IN PATIENTS WITH ACUTELEUKEMIA AND ITS CLINICAL IMPLICATION

用双抗夹心ＥＬＩＳＡ方法检测３４例成人急性白血病患者脑脊液中可溶性白细胞介素２受体（ｓＩＬ－２Ｒ），７例中枢神经系统白血病（ＣＮＳＬ）初诊或复发患者脑脊液中ｓＩＬ－２Ｒ水平较７例ＣＮＳＬ已缓解及２０例无ＣＮＳＬ急性白血病患者明显升高（Ｐ＜０．０５）。ＣＮＳＬ已缓解者脑脊液中ｓＩＬ－２Ｒ接近非白血病对照水平（Ｐ＞０．０５）。脑脊液中ｓＩＬ－２Ｒ变化与胞脊液白细胞计数、蛋白、糖、氯化物等指标无明显统计学意义，但与ＣＮＳＬ患者病理细胞有无、化疗疗效相关。脑脊液中ｓＩＬ－２Ｒ水平不受其血清水平影响。提示监测急性白血病患者脑脊液中ｓＩＬ－２Ｒ水平有助于ＣＮＳＬ的诊断及疗效评定。

he soluble interleukin-2 receptor (sIL-2R) in thecerebrnspinal fluid (CSF) was assayed with ELISA in34 cases of leukemia and 35 cases of other diseases.The value of sIL-2R was high in the patients with cen-tral nervous system leukemia (CNS-L) and returned tonormal when CNSL was controlled by intrathecalchemotherapy. The values in patients without CNS-Lwas normal. The value of sIL-2R showed no relationsto other parameters except for leukemia cells in CSF.There was no relationship between the values of slL-2R in CSF and in serum. It suggested that determina-tion of sIL-2R in CSF might be useful in the diagnosisand prognosis of CNS-L.