摘要
1990年6月25日,上海发生一起钴辐射事故,7人在短时间内受到大剂量、高剂量率、相对均匀的γ线照射。其中两例受照剂量达11Gy和12Gy,诊断为极重度骨髓型急性放射病。两例在紧急情况下分别于受照后第7天和第11天进行了HLA半相合的骨髓移植(BMT)。其中一例53岁,骨髓完全植活,造血重建,并成功防治了急性移植物抗宿主病,但于照后第90天死于间质性肺炎。另一例56岁,于受照后第25天死于肺部出血和深部真菌感染。作者对事故性放射病骨髓移植的适应证、追加预处理等问题进行了讨论。
n the  ̄(60)Co radiation accident happened in Shanghaion June 25,1990,seven people were accidentally ex-posed to high doses of relatively homogeneous totalbody radiation in a very short time.Two victims,whoreceived estimated doses of 11 and 12Gy,respectively,were diagnosed as extremely severe bone marrow formof acute radiation sickness, In the critical condition,they received HLA-haplotype identical bone marrowtransplantation at day 7 and day 11 after radiation,re-spectively. One patient,53 years old,had completeengraftment and hematopoietic recovery after trans-plantation,which was demonstrated by bone marrowhistology, HLA typing,cytogenetics and moleculartechniques,Acute graft-versus host disease(GVHD)was successfully controlled.Unfortunately,he died ofinterstitial pneumonitis at day 90 after the accident.Another,56 vears old,survived for 25 days after radi-ation and died of pulmonary hemorrhage and systemicfungal infection.
出处
《中华血液学杂志》
CAS
CSCD
北大核心
1995年第10期511-513,共3页
Chinese Journal of Hematology
关键词
辐射事故
放射病
急性
骨髓型
骨髓移植
Radiation accident Acute radiation sickness Bone marrow transplanta-tion