先天性视网膜色素上皮肥大对家族性腺瘤性息肉病的筛查

SCREENING VALUE OF CONGENITAL HYPERTROPHY OF THE RETINAL PIGMENT EPITHELIUM FOF FAMILIAL ADENOMATOUS POLYPOSIS

对８例家族性腺瘤性息肉病（ＦＡＰ）５名Ｉ级高危亲属和１００例对照组作眼底色素病变研究。结果表明：先天性视网膜色素上皮肥大对ＦＡＰ有筛检价值，若色素斑有晕圈、数量≥４颗、病变为双眼且位于后极部，则ＦＡＰ的可能性很大。

Pigmented ocular fundus lesions were studied in 8 patients with familial adenomatous polyposis(FAP),5 first-degree relatives at risk and 100 controls。The result indicates that congeni-tal hypertrophy of the retinal pigment epithelium(CHRPE)possesses value of screening for FAP,It is considered that the probability of presence of FAP would be high if the retinal pigment lesions re-veal the following characteristics:pigment lesion surrunded with halo,4 or more in number,binocu-lar distribution and locating at the posterior pole of fundus。