巨噬细胞对人工晶体植入术后兔眼晶体上皮细胞增生的影响

Lens epithelial proliferation induced by macrophages after iutraocular lens implantation in rabbits

为探讨人工晶体植入术后晶体后囊混浊的机制，采用兔眼后房型人工晶体植入术后，术眼前房内注入巨噬细胞悬液的方法，用透射电镜观察术后不同时间晶体后囊形态学变化。结果表明：人工晶体植入术后１周，晶体后囊前即覆盖一层晶体上皮细胞，排列整齐，结构正常。观察至６个月，无明显变化。前房注入巨噬细胞组，１周亦可见晶体后囊覆盖一层上皮细胞，细胞内大量微丝形成；２周可见晶体上皮细胞周围胶原纤维形成；３个月可见晶体后囊前２或３层上皮细胞增生，细胞周围大量胶原纤维形成。提示：巨噬细胞促进人工晶体植入术后晶体后囊混浊。

To approach the effect of intraocular lens implantation on the mechanism of posterior capsular opacification,the pathological changes of posterior lens capsule after intraocular lens im-plantation in rabbits were observed by transmissiOn electron microscopy.The results were as fol-lows:In the control group,1 week after the operation and the injection of the medium of the macrophage suspension,the lens posterior capsule was covered by a layer of lens epithelium and until post-operative 6 months,the lens epithelium remained normal. In the experimental group,1 week after the operation and the injection of the macrophage suspension into the anterior chamber,micro-filaments appeared in the cytoplasm of lens epithelial cells, after 2 weeks,the lens epithelial cells produced collagen fibrils in the extracellular matrix and until postoperative 3 months,2-3layers of the lens epithelium proliferated in front of the posterior capsule and a large amount of collagenous fibers were formed around the cells. It is suggested that the rnacrophage promote the lens epithelial proliferation and the posterior capsular opacification.