摘要
为了探讨血清Ⅲ型前胶原氨基端肽(N-PⅢP)在慢性肝病中的诊断作用,采用放射免疫的方法检测了15例慢性迁延型肝炎(CPH)、15例慢性活动型肝炎(CAH)、18例肝硬化(LC)和10例正常人的血清N-PⅢP含量,并对全部患者进行肝活检和肝组织切片的纤维染色并分级。结果显示:CAH和LC组血清N-PⅢP含量显著高于CPH和正常对照组(P<0.005),血清N-PⅢP含量与肝组织的纤维化程度有显著相关性(P<0.005)。提示,血清N-PⅢP可以反映肝纤维化程度和慢性肝病的活动度,可作为临床上判断肝病进展及预后的一项指标。
o inquire into the diagnostic significance of type Ⅲ procollagen N-aminoterminal peptide(N-PⅢP)in chronic liver disease,serum N-PⅢP level;were measured by RIA in 15 patients with chronicpersistent hepatitis(CPH),in 15 with chronic active hepatitis(CAH),in 18 with liver cirrhosis,and in10 healthy subjects. The serum N-PⅢP level was significantly elevated in the patients with CAH, cir-rhosis when compared with the healthy subjects and CPH(P<0.005).A stong positive corrlation wasobserved between the serum PⅢP levels and the degree of hepatic fibrosis(P<0.005).The results in-dicated that serum N-PⅢP could reflect the degree and activity of the chronic liver disease,and could beused as a marker to judge the development and prognosis for liver disease.
基金
河南省医科院