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血清Ⅲ型前胶原氨基端肽在慢性肝病中诊断作用

The diagnostic role of serum type Ⅲ procollagen N-aminoterminal peptide in chronic liver deas-esa
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摘要 为了探讨血清Ⅲ型前胶原氨基端肽(N-PⅢP)在慢性肝病中的诊断作用,采用放射免疫的方法检测了15例慢性迁延型肝炎(CPH)、15例慢性活动型肝炎(CAH)、18例肝硬化(LC)和10例正常人的血清N-PⅢP含量,并对全部患者进行肝活检和肝组织切片的纤维染色并分级。结果显示:CAH和LC组血清N-PⅢP含量显著高于CPH和正常对照组(P<0.005),血清N-PⅢP含量与肝组织的纤维化程度有显著相关性(P<0.005)。提示,血清N-PⅢP可以反映肝纤维化程度和慢性肝病的活动度,可作为临床上判断肝病进展及预后的一项指标。 o inquire into the diagnostic significance of type Ⅲ procollagen N-aminoterminal peptide(N-PⅢP)in chronic liver disease,serum N-PⅢP level;were measured by RIA in 15 patients with chronicpersistent hepatitis(CPH),in 15 with chronic active hepatitis(CAH),in 18 with liver cirrhosis,and in10 healthy subjects. The serum N-PⅢP level was significantly elevated in the patients with CAH, cir-rhosis when compared with the healthy subjects and CPH(P<0.005).A stong positive corrlation wasobserved between the serum PⅢP levels and the degree of hepatic fibrosis(P<0.005).The results in-dicated that serum N-PⅢP could reflect the degree and activity of the chronic liver disease,and could beused as a marker to judge the development and prognosis for liver disease.
出处 《中华医学检验杂志》 CSCD 1995年第6期361-363,共3页
基金 河南省医科院
关键词 血清 Ⅲ型 胶原氨基端肽 肝硬变 慢性 Procollagen Ⅲ peptidede Cirrhosis
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  • 1陈美龄,中华内科杂志,1985年,24卷,增刊,30页
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