缺锌对大鼠生长发育的影响

Affection of growth of zinc deficiency growing rats

为了验证锌对婴幼儿生长发育的影响，用不同含锌量的人工半合成词料，饲养生长中的大鼠。对其生长、发育过程进行了详细的观察。结果锌严重缺乏组大鼠平均摄食总量仅为对照组的４３％左右，不同程度缺锌组大鼠平均体重增加量与饲料含锌量间呈显著正相关（ｒ＝０．９９６），严重缺锌组食物转化率为３．１９７，补锌的营养生理作用是显著提高了大鼠的食物利用率，但饲料含锌量提高２５倍，其食物转化率的改变却非常小。结合多项血液学及有关生化参数的分析测试结果，讨论了锌缺乏对大鼠生长的影响和缺锌诊断的综合评价方法。

ifty male Sprague-Dawley rats with an averagelive mass of 42± 4g were divided into 5 groups of 10 an-imals each. An artificial semi-systhesis diet was given tothe animals. Group 1 received a control diet (32. 2mgZn/kg DM) , and group 2 a zinc deficient diet (3. 4mgZn/kg DM) ad libitum. The animals of group 3 werepair fed to group 2 with a diet (84. gmg Zn/KgDM).Diets of group 4 and 5 contained zinc (4. 4 and 5. 5kgZn/μg DM) , respectively. The two groups also pair fedto group 2. The food intake and live mass gain were ob-served every day. After 26 days of experiment, the ani-mals were decapitated; the blcod samples were collectedfor the analysis of serum zinc, zinc binding capacity,and alkaline phosphatase.