碘染色在早期食管癌内镜诊断中的应用

Lugol’s solution in endoscopic diagnosis of earlyesopbageal Cancer

早期的粘膜和粘膜下食管癌有时很难发现和定位，Ｌｕｇｏｌ’ｓ液染色可对早期诊断提供极大的帮助。作者对普查中发现的食管癌高危人群进行了内镜检查。其中对１２０例可疑早期食管癌或癌前病变者，在内镜检查中进行Ｌｕｇｏｌ’ｓ液染色和指示性活检，并对病灶不着色的９８例作活组织检查。其中６０例报告为食管鳞癌（占６１．２％），３８例为中度和重度不典型增生（占３８．８％）。碘染色法可帮助确诊、定位以及确定有无卫星病灶等，大大减少了早期微小恶性病灶的漏诊。对食管癌的早期；陆床诊断与治疗有重要意义。

bout 1500 high-risk subjects of esophageal cancerwere found during screening by balloon cytology and allof them were examined endoscopically. Among them,120 were considered as having early esophageal cancerand precancerous lesions. During the examination,I.ugol's solution staining was used and guiding biopsywas taken. 98 subjects with unstained lesions werefound , and biopsy showed early esophageal cancer in 60(61. 2 % ) and moderate and severe dysplasia in 38 (38.8% ). It is usually extremely difficult to detect and lo-calize the very early esophageal mucosal and submucosalcarcinoma. But endoscopic examination and usingLugol’s solution staining with multiple spots biopsy fromunstained area are of great assistance. Minute malignantlesions may not be overlooked.