食管癌放射免疫治疗的实验研究

Experimental study of radioimmunotherapy forxenograft of human esophageal carcinoma

为了进一步探讨食管癌治疗的新途径。作者用￣（１３１）Ⅰ标记单抗ＭＧｂ２对人食管癌细胞株Ｅｃａ－１０９裸鼠移植物试行放射免疫治疗。荷瘤裸鼠３０只分五组，设各对照组及腹腔给药、瘤内给药两治疗组，一次性给药１８．５ＭＢｑ后比较各组移植物体积及其生长抑制率。结果提示￣（１３１）Ⅰ－ＭＧｂ＿２对人食管癌裸鼠移植物有较强抑制作用，且可持续一定时间，在１８．５ＭＢｑ药量时瘤内给药抑瘤效果优于腹腔给药。

Using nude mice bearing human esophageal carci-noma strain Eca 109 as models of tumor , we tested thetherapeutic efficiency of 131 labelled monoclonal antibodyMGb2 A 4-week experimental study was carried out in5 treatment groups: group A , buffer, group B, unla-belled MGbz ; group C, 131 I-labelled normal mice IgGand group D, 131 I-labelled MGb2 18. 5MBq. All nudemice above were given agents intraperitoneally. Ingroup E, the animals were given 131 I-labelled MGb218. 5MBq by intratumoral administration. The resultsshowed that from the second week, in group D and Ethe tumor volume was remarkably decreased as com-pared with that of the other 3 groups (P<0. 01 or P<0. 05). In the fourth week the mean volume in group Dand E were 0. 55 cm3 and 0. 23cm3 , while in group A ,the volume was 1. 43cm3. The inhibition rate of tumorgrowth in group D and E was higher than in othergroups from the second week (P<0. 01) , especialy inthe third and fourth week with a mean value of 62.4% , 61. 5% and 82. 2% , 83. 9% respectively. Therewere no significant differences between group A, B,and C in tumor volurne or growth inhibition rate.