摘要
为提高脂质体对药物的包裹率,作者对制备方法进行研究。运用pH调整法这一种新的药物梯度负载技术制备阿霉素脂质体。选用阳离子交换树脂分离法去除游离药物。结果表明,该法制备过程灵活、简便,包裹率高,可达95%;电镜检测脂质体为单室球形,平均粒子直径为103nm。这些方法对脂质体的工业化生产具有潜在的实用价值。
We established a more suitable methodology for preparing liposomal adriamycin (Lipo-ADM) by a remote loading technique.This procedure is convenient,simple with an entrapment efficiency of 95%.The mean diameter of liposome is about 100nm showing unilamellar spherical shape. The leakage ratio is about 10% within 24hr. Those characteristics fit for clinical demand.
出处
《中华医学杂志》
CAS
CSCD
北大核心
1995年第10期614-616,共3页
National Medical Journal of China