阿霉素脂质体的制备及其物化特性研究

Preparation and characterization of liposomal adriamycin

为提高脂质体对药物的包裹率，作者对制备方法进行研究。运用ｐＨ调整法这一种新的药物梯度负载技术制备阿霉素脂质体。选用阳离子交换树脂分离法去除游离药物。结果表明，该法制备过程灵活、简便，包裹率高，可达９５％；电镜检测脂质体为单室球形，平均粒子直径为１０３ｎｍ。这些方法对脂质体的工业化生产具有潜在的实用价值。

We established a more suitable methodology for preparing liposomal adriamycin (Lipo-ADM) by a remote loading technique.This procedure is convenient,simple with an entrapment efficiency of 95%.The mean diameter of liposome is about 100nm showing unilamellar spherical shape. The leakage ratio is about 10% within 24hr. Those characteristics fit for clinical demand.