摘要
为了研究ｐ５３基因的拮抗基因ＭＤＭ２基因在急性白血病中的表达，作者用逆转录聚合酶链（ＲＴ－ＰＣＲ）方法研究了４０例急性白血病患者ＭＤＭ２基因的表达，发现５２．５％的急性白血病患者有较高水平的ＭＤＭ２基因的表达，ＭＤＭ２的表达在急性淋巴细胞白血病与急性非淋巴白血病之间无明显差别，提示ＭＤＭ２基因可能在急性白血病的发病中起了一定的作用。
In order to study expression of MDM2 gene,antagonist of tumor suppressor gene p53 in acute leukemia,forty acute leukemia patients were tested using RT-PCT to evaluate expression level of MDM2 gene Overexpression of MDM2 gene was found in 52.5% patients(21/40).No significant relations were found between the level of MDM2 gene expression and FAB subtypes of acute leukemia.It is suggusted that the over-expression of MDM2 gene may play a role in acute leukemia.
出处
《中华医学杂志》
CAS
CSCD
北大核心
1995年第11期686-688,共3页
National Medical Journal of China
基金
国家自然科学基金
