摘要
以离体肾小管上皮细胞为研究对象，重金属镉为损伤因素，观察了镉致肾小管上皮细胞损伤时细胞内钙稳态的变化及其与肾小管上皮细胞损伤之间关系。结果表明，用重金属镉处理后，肾小管上皮细胞内胞浆游离钙水平明显升高，且同时伴有一系列超微结构的损害；钙通道阻滞剂异丙嗪表现出明显的阻断、保护作用，本实验提示在重金属镉致肾损伤过程中钙超载机制起着很重要的作用。
hanges of intracellular calcium homeostasis in epithelial cell damage of renal tubules caused by cad-mium and its relationship with the damage were stud ied in isolated t ubuiar cells of rabbits.Resultsshowed levels of free calcium(Ca￣(++) )in tubular cytoplasm increased significantly with the treatment of cadmium,and a series of cellular ultrastructure were damaged;A calcium channel blocker,phenoth- iazine,showed blocking and protecting effects on it.This suggested calciurn overload played a very im-portant role in kidney damage caused by cadmium.
出处
《中华预防医学杂志》
CAS
CSCD
北大核心
1995年第3期153-155,共3页
Chinese Journal of Preventive Medicine
基金
国家自然科学基金
