摘要
采用中性粒细胞(PMN)与玻璃珠粘附和PMN与血管内皮细胞(EC)粘附两种模型,以肿瘤坏死因子(TNF),作为PMN的刺激因子,研究糖皮质激素(GC)对TNF引起的大鼠PMN粘附的影响,同时给予糖皮质激素受体(GR)阻断剂RU38486观察GR在粘附中的作用。结果发现,TNF能明显增强大鼠PMN的粘附(P<0.01);Dex不能抑制经TNF预处理的PMN的粘附(P>0.05),但有一定的预防作用;经TNF预处理再同时给予Dex和RU38486的PMN粘附同样明显增强(P<0.01)。
TNF was used as a stimulating factor to study the effects of glucocorti- coid(GC)on polymorphonuclear leucocyte(PMN)adhesion.The results showed that tumor necrosis factor(TNF)could increase the PMN adhesion markedly,and Dex could not inhibit the PMN adhesion induced by TNF,but it had a certain effect of prevention. PMN adhesion was increased prominently when Dex and RU 38486 were given after TNF pretreatment.
关键词
中性粒细胞
粘附
糖皮质激素
肿瘤坏死因子
Polymorphonuclear(PMN)
Adhesion
Glucocorticoid recepter(GR)
Glucocorticoid(GC)
Tumor necrosis factor(TNF)
