摘要
采用大白鼠15%Ⅲ度烧伤模型,探讨了影响碱性成纤维细胞生长因子(bFGF)促进烧伤创面愈合的因素。结果发现,烧伤创面早期切痂可保持bFGF的活性。40天创面愈合率达84.0%,而未切痂组愈合率仅9.0%。肝素可增强bFGF促进创面肉芽组织生长、毛细血管增生、纤维母细胞增殖及细胞DNA合成。创面感染的控制有利于保护bFGF的活性。伤后1周开始使用bFGF为适宜时期。
The factors influencing basic fibroblast growth factor(bFGF)to improve wound healing in severe burn were studied. Rats were subjected to 15% Ⅲ° burn. The results showed that high activity of bFGF was maintained after escharectomy in early period. In treated group 84.0% of rats wound healing was observed on the 40 th day, while it was 9.0% in control group. Heparin could enhance activity of bFGF to stimu- late formation of granulation tissue, regeneration of capillary, proliferation of fibroblast and DNA synthesis. Control of infection was beneficial to preserve activity of bFGF. The authors believe that the proper time to use bFGF is one week after injury.
