摘要
作者对５００例原发性胃腺癌之常规病理切片进行了光镜观察，发现其中１２例有不等量肝细胞癌样分化区域。对此１２例进行了形态学详细观察，并对其中１１例做了ＡＦＰ（甲胎球蛋白）、ａ＿１—ＡＴ（ａ＿１—抗胰蛋白酶）、ａ＿１—ＡＣＴ（ａ＿１—抗糜蛋白酶）、及ＣＥＡ（癌胚抗原）免疫组化染色，观察肝样癌区的反应。发现９例呈现不同程度ＡＦＰ阳性，而对照组１０例均为阴性；１０例ＣＥＡ为弱阳性，２例为阳性；ａ＿１—ＡＴ、ａ＿１—ＡＣＴ两组无差异。作者还探讨了这种类型胃腺癌的临床与病理形态学特点及其与ＡＦＰ的关系等，并认为胃肝样腺癌是胃腺癌中较少见的一个亚型。
AbstractRoutine examination of pathologic sections in 500 cases of
primary gastric adenocarcinomas wascarried out by light microscopy.
Regions of hepatocellular carcinomatoid differentiation
werediscovered in 12 of the 500 cases,In 11 of them ,histopathologic
features were described in great detailand the hepatocellular
carcinomatoid regions were studied by four kinds of
immunohistochemistricalmethods. The results indicate that positive
staining for AFP was seen in 9 cases but negative in 9controls
,weakly positive for CEA in 10 cases , but strongly positive in 8
controls. Staining for a_1-ATand a_1-ACT showed no differences as
compared to controls. The clinical pathological features and
itsrelationship with AFP are discussed.It is suggested that hepatoid
gastric adenocarcinoma is a subtypeof gastric adenocarcinoma.
出处
《中华肿瘤杂志》
CAS
CSCD
北大核心
1995年第1期56-59,共4页
Chinese Journal of Oncology
