肝动脉化疗栓塞术及生物反应调节剂治疗晚期原发性肝癌的探讨

HEPATIC ARTERY CHEMOTHERAPY-EMBOLIZATION AND BIOLOGICAL RESPONSE MODIFIERS FOR LATE HEPATIC CARCINOMA

作者以肝动脉化疗栓塞术和生物反应调节剂两种手段交替使用治疗６３例晚期原发性肝癌。１年生存率为５０．８％，２年生存率为２２％，疗效优于单独使用肝动脉化疗栓塞术者，且患者治疗后副作用轻、少。结果表明，两种手段交替使用可能产生相加和协同作用，有利于提高晚期肝癌的治疗效果。

AbstractSinec 1989,63 cases of far-advanced cases of primary hepatic carcinoma were treated byalternating courses of hepatic artery infusion chemotherapy-embolization(HAIE)andbiotherapy.For chemotherapy, mitomycin C,epiadriamycin(with lipiodol)and 5-Fu wereused.Biotherapy consisted of systemic administration of γ-interferon,interleukin 2 and transferfactor.Forty-four patients with late hepatic carcinoma were treated with HAIE alone,HAIEplus biotherapy resulted in more marked reduction in tumor size and serum AFP level as com-pared to that in the HAIE-treated patients. The 1-and 2-year survival rates for the twogroups were 50.8 % and 22 % versus 40.9% and 6.8%,respectively.