吉林省与日本秋田县非何杰金淋巴瘤的免疫分型与临床关系（附219例报告）

IMMUNOPHENOTYPING AND CLINICAL MANIFESTATIONS OF NHL IN JILIN PROVINCE AND AKITA COUNTY

对吉林省与秋田县２１９例非何杰金淋巴瘤（ＮＨＬ）的免疫分型与临床进行了对比分析，结果发现：吉林省Ｂ－ＮＨＬ的发生率高，Ｂ、Ｔ－ＮＨＬ之比为５．１：１，其病理类型以弥漫大细胞性居多。秋田县以免疫母细胞性居多。两地区低度恶性者均占少数。Ｂ－ＮＨＬ的完全缓解（ＣＲ）率及生存期明显优于Ｔ－ＮＨＬ（Ｐ＜０．０５）。

AbstractThis was a comparative study of NHL in Jilin Province , China(JPC)and Akita county,Japan(ACJ).A total with 219 cases of their clinical features analyzed. The results indicated thatin both areas, BNHL predominated with a B to T cell ratio of 5.1:1(JPC)and 2.4:1(ACJ)respectively. Histologically B-NHL of defuse large-cell type was most commonly seen ,the fre-quency of which was higher in JPC(61.5%)than in ACJ(37.2%).However ,immunoblasticB-NHL was of common occurence in ACJ (26 out of 91 cases).In contrast, immunoblastic lym-paoma of T cell lineage was very common in both areas , accounting for a half of all T-NHL.Most of the patients were treated with CHOP or COPP protocol , but the responses differred be-tween the two phenotypes of NHL. Patients with B-NHL responded favorably to chemotherapy,with complete response(CR)in 54 of 70 treated cases(77.0%)in ACJ and 47 of 82 treated cases(57.3%)in JPC. The 3-year disease-free survial rate was 44%and 37%, respectively. The re-sponse to treatment in T-NHL patients was inferior with a CR rate of 59%in JPC cases. Only 2in each series of patients kept the remission over 1 year.