急性白血病自体骨髓移植结合强烈化疗后生存期的分析（附11例报告）

DISEASE-FREE SURVIVAL OF ACUTE LEUKEMIA PATIENTS RECEIVING AUTOLOGOUS BONE MARROW TRANSPLANT FOLLOWING INTENSIVE CHEMOTHERAPY-A Report OF 11 CASES

作者报告１１例急性白血病自体骨髓移植结合强化治疗的结果。首次缓解期８例，第２次缓解期３例，移植时中位年龄３８岁，预处理主要用ＴＡＣＣ方案。其中３例急性早幼粒细胞白血病患者的骨髓用普鲁卡因联合加热方法进行体外净化。移植后全部患者造血功能得到重建。随访到１９９４年５月止，中数缓解期与生存期为３１（６～５７）个月，７例移植后已持续完全缓解６～５７个月，中位数为４２个月，４例在骨髓移植后曾发生感染，均用抗生素治愈。

AbstractEleven cases of acute leukemia patients were treated with autologous bone marrow transplan-tation(ABMT)following intensive chemotherapy with TACC protocol. Among them , eight werein first remission , three in second remission. The median age was 38 years(24～45 years). Bonemarrow was purged in vitro before transplantation with procaine and hyperthermia in three caseswith acute promyelocytic leukemia. In all patients, ABMT was successful. The results of treat-ment are as follows : as of May , 1994, the median remission and disease-free survival period was31 months(6～57) , seven cases have been in complete remission for 6～57 months(median 42months ) after treatment and are still alive. In four cases, ABMT was complicated by infectionbut it was controlled by antibiotics.