卡铂、阿霉素、环磷酰胺联合治疗晚期乳腺癌的临床疗效

THE CLINICAL EFFICACY OF CAC REGIMEN IN THETREATMENT OF ADVANCED BREAST CANCER

作者采用ＣＡＣ方案（卡铂十阿霉素十环磷酰胺）治疗晚期乳腺癌２７例，其中１８例（包括辅助化疗８例）为初治。２０例病人有２处以上转移。卡铂３００ｍｇ／ｍ￣２，静滴，ｄ＿１或１５０ｍｇ／ｍ￣２，ｄ＿（１、２）；阿霉素４０ｍｇ／ｍ￣２，静冲，ｄ＿３；环磷酰胺５００ｍｇ／ｍ￣２，静冲，ｄ＿（３、１０）。２８天为一周期。总有效率６３％（１７／２７），其中完全缓解５例（１８％），部分缓解１２例（４４％），中位缓解期９个月，中位生存期１７个月。对软组织转移有效率为６１％（１１／１８），肺转移为３／５，肝转移和胸膜转移分别为３／３和４／４，骨转移为１／１０。初治者有效率７２％（１３／１８），复治者４／９。本组胃肠反应不重；未发现肾毒性；白细胞减少（Ⅱ、Ⅲ度）占８９％。作者认为，ＣＡＣ方案是治疗晚期乳腺癌的有效方案。

Abstract Twenty seven Patients with advanced breast cancer were treated with CAC(carboplatin,adriamycin,cyclophosphamide)regimen. Eighteen patients had no prior chemotherapy. Carbo-platin was given 300 mg/m￣ 2 intravenously(IV),on day 1 or 150mg/m￣2 on day 1,2,adriamycin 40mg/m￣2 IV on day 3,cyclophosphamide 500 mg/m￣2 IV on day 3,10.The treatment was recycledevery 28 days.The overall objective response was 63%(17/27)with a CR rate of 18%(5/27).The median duration of response was 9 months and median survival time was 17 months.The re-sponse rate of soft tissue metastasis was 61%(11/18).Lung metastasis responded in 3/5,livermetastasis in 3/3,pleura metastasis in 4/4,bone metastasis in 1/10.The response rate of previ-ously untreated patients was 72%(13/18).The gastrointestinal reaction was mild.No renal toxi-city was observed.Leukopenia(WHO grade Ⅱ,Ⅲ)was seen in 89%.These results indicate thatCAC is an effective regimen for advanced breast cancer.