钙调素阻滞剂对原代肺癌细胞化疗敏感性的作用

EFFECT OF CALMODULIN ANTAGONIST ON CHEMOSENSITIVITY OF PRIMARY CULTURED LUNG CANCER CELLS

作者应用ＭＴＴ比色法，首次分析了钙调素阻滞剂三氟拉嗪（ＴＦＰ）对２８例原代培养的肺癌细胞的化疗敏感性的作用。本组鳞癌２０例，腺癌７例，小细胞癌１例。结果显示，ＴＦＰ能显著增强长春新碱、阿霉素、足叶乙甙三种药的体外抗肺癌细胞活性，而对顺铂则无明显影响。ＴＦＰ使长春新碱体外抗肺癌有效率由３２％增至６４％，阿霉素有效率由２１％增至５４％，足叶乙甙有效率由４６％增至６１％，而且该增强作用有剂量依赖性特点，随抗癌药物浓度增加而作用增强。该药对化疗的增敏作用与肺癌细胞的特殊耐药机制有关。本结果提示，ＴＦＰ可能在临床肺癌化疗中有较好的化疗增敏作用。

AbstractThe effect of calmodulin antagonist trifluoperazine(TFP)on in vitro drug senstivity of pri-mary cultured lung cancer cells was studied in 28 cases with MTT assay.TFP was found to en-hance significantly the anticancer activities of VCR,ADR and VP_(16)(P<0.01 or <0.05).ButTFP could not sensitize tumor cells to DDP.TFP may therefore be useful as an adjunet inchemotherapy of lung cancer.