祛痰宁的抗炎、止咳、平喘作用

The Antiinflammatory, Antibechic and Antiasthmatic Actions of Que Tan Ning

祛痰宁0.10—0.40g/kg ig给药能明显抑制鸡蛋清引起的大鼠足肿胀;0.05—0.20g/kg ip及0.10—0.40g/kg ig给药时,对巴豆油引起的小鼠耳肿胀有极强的抑制作用;0.10—0.40g/kg ig给药对浓氨水引起的小鼠咳嗽也有明显的抑制作用,但平喘作用不明显;昆明种小白鼠LD_(50)ig为4.64±0.84g/kg,ip为0.58±1.18g/kg。

0.10g/kg of Que Tan Ning is effective in relieving cough caused by the irritation of ammonia water. The effect of 0.40g/kg of Que Tan Ning is equivalent to that of 0.05g/kg of codeine. 0.1-0.4g/kg of Que Tan Ning ig have the inhibition effect to the inflammation caused by 0.1 ml of 10% egg white and 0.3 g/kgig and 0.05g/kg ip has an obvious inhibiting effect on the ear-sweelling caused by croton seed oil of mice. There exists a distinctive relationship of quantity. The LD50 is 4.46 ?.84g/kg ig Long-tem toxicity experiments on rats and dogs have shown that Que Tan Ning has little toxic and side-effects The Que Tan Ning may become a new drug for the treatment of respiratory diseases.