山海丹V号对大鼠实验性心肌缺血的作用

Actions of Shanhaidan V on Experimental Myocardial Ischemia in Rads

甩结扎冠脉制造大鼠心肌缺血模型,结扎冠脉15分钟后经十二指肠给药,记录给药前后心电图及用N—BT染色法定量测定结扎3小时后心肌梗塞面积。结果,山海丹Ⅴ号能在给药后15、45、65、105、165分使大鼠心率减慢(P<0.05～0.01);结扎冠脉后15分各组ST段均明显升高,山海丹Ⅴ号1.4、2.8g/kg能明显降低ST段(P<0.01);山海丹Ⅴ号(0.7、1.4、2.8g/kg)能减少心肌梗塞面积(P<0.01)。

To rat model of myocardial ischemia induced by liga-tion of coronary artery. Shanhaidan V was given via duodenum 15 minutes after ligation. ECG and quantitative measurement of the area of infarction by N -BT staining 3 hours after ligation were performed before and after drug administration. Results showed' that the heart beat rates 15. 45. 65. 105. 165 minutes after administration of Shanhaidan V were slowed down (P<0. 05 - 0. 01). ST segment in all groups markedly elevated 15 minutes after ligation. When Shanhaidan V was given in 1. 4. 2. 8 g/kg dose, ST segment markedly lowered (P<0. 01)., Shanhaidan V : (0. 7, 1. 4. 2. 8 g/kg) also decreased the area of infarction (P<0..01). Conclusion: Shanhaidan V ameliorated the degree of ischemia, in rat's ischemic cardiac muscle; reduced the infarct area and slowed down rate . of heart beat.