系统性红斑狼疮肾炎患者外周血红细胞膜C_3b受体活性与辨证分型的关系

Relationship Between Syndrome—typing and Activity of C_3b Receptor of Peripheral Erythrocytic Cell-membrane in Nephritic Patient of Systemic Lupus Ery-thematosus (SLE--GN),

本文选择外周血红细胞膜C_3b受体花环率(E—C_3bR)作为红细胞膜C_3b受体活性的指标。观察了系统性红斑狼疮肾炎(SLE—GN)患者中医辨证分型与E—C_3bR的关系。结果表明,4个证型的E—C_3bR较正常人组均下降(P<0.01),其下降顺序为正常人组>气阴两虚组>脾肾阳虚组>肝肾阴虚组>热盛湿蕴组;热盛湿蕴、肝肾阴虚多见于活动期,分别占各自例数的78. 57％和66.67％,而脾肾阳虚、气阴两虚多见于稳定期,分别占各自例数的63.64％和71.43％;疾病活动期、稳定期病人的E—C_3bR均较正常人低,尤以活动期病人更明显(P<0.01)。

By adopting the E -C3bR applied in foreign countries as an index for C3b activity of erythrocytic cell- membrane, we observed the relationship between TCM syndrome typing and E -C3bR in SLE -GN. Results were as follows: E -C3bR in 4 syndrome types were all lower than normal person (P<0. 01) in the order of normal person>Yang deficiency of spleen -kedney group>Yin deficiency of liver- kidney group > accumulated dampness and exuberant heat group. The last two types were often seen in active stage of the illness, amounting to 78. 57% and 66. 67% respectively: while the other 2 types, in stable stage, amounting to 63. 64% and 71. 43%. The E - C3bR was lower than normal person in both stages, especially at the active stage (P<0. 01).