食盐加硒对消化系统肿瘤的防治观察

THE PREVENTIVE ROLE OF SELENIUM SALT ON DIGESTIVE SYSTEM CANCERS

江苏省扬中县在食盐中添加１５ｐｐｍ亚硒酸钠，观察微量营养元素硒对癌肿的干预作用，该县改盐前健康成人血硒含量为０．０７２±０．０２２μｇ／ｍｌ，观察结束前对照照居民血硒值为０．０８５６±０．０１７μｇ／ｍｌ，硒盐区居民为０．０９６２±０．０１３５μｇ／ｍｌ．化学测定普通盐中硒（─），加硒盐五年平均１２．２３８±１．９６９ｐｐｍ。硒盐区５个乡镇１２．６万人，普通盐区５个乡镇１０．４万人。结果显示：总癌亡、胃癌亡有较肯定的效果，４年平均死亡率分别下降３９×１００－５及２１×１０－５或１２％及１８％。肝癌和食管癌可能也有作用，后四年比前二年分别下降１０×１０－５及１５×１０－５或２２％及１５％。对结肠、直肠、肛门癌和肺癌未见有何作用。硒盐区１９８７～１９９３年粗死亡率的线性回归分析示总癌亡及胃癌亡有显著性，年死亡率分别下降１０．２８×１０－５及６．３２×１０－５．表明硒盐是纠正缺硒，降低癌亡安全有效，价廉可行的方法。

The present patper reported the preventive effect of sodium selenite salt( SSS) on cancer death in Yangzhong County during 1989～1993.The treated group consisted of 126, 000 persons taken daily the SSS which contained around 12 ppm sodium selenite. The control group consisted of 104,000 persons who took only ordinary salt without sodium selenite. In the treated group,the blood selenium concentration before treatment was .072±0.022μg/ml, and at the end of 5 yaers it was 0.0962±0.0135μg/ml,,while it was 0.0856±0.017μg/ml in the control group. The mortality rates of all cancers and gastric cancer declined 12% and 18% respectively( P< 0. 05) ,and liver and esophageal cancers also decreased somewhat.The SSS had no effect on the mortality rates of colon,rectum, anus and lung cancers.There was no side- effect of SSS during the 5 study years.