关于肺癌与肺结核联系性的回顾性队列研究

RETROSPECTIVE COHRT STUDY ON ASSOCIATION OF LUNG CANCER WITH PULMONARY TUBERCULOSIS

１９８７年～１９８９年期间对上海结防系统自１９７２年起登记的肺结核病例进行了回顾性队列研究，以检验肺癌与肺结核有联系性的假设。对在１９５７年１月１日前出生且常住户口在上海市区的３０３７３名肺结核病例（男１９７０９例，女１０６６４例）进行随访直至１９８６年。男女肺结核病例中肺癌ＳＭＲ分别为１．３８和２．７３．均有统计学显著意义。调整吸烟因素后，调整的肺癌ＳＭＲ男性为１．７２（９５％置信区间：１．１１～２．５３），女性为２．７９（９５％；置信区间：１．７９～４．１４）．肺结核病例中肺癌危险性升高不是吸烟因素影响的结果。异菸肼治疗和Ｘ线胸透也不能解释升高的危险度。

A retrospective cohort study among tuberculosis patients registered in Shanghai TB Registry since 1972 was carried out during 1987-1989 for testing the hypothesis on association of lung cancer with pulmonary tuberculosis.A total of 30, 373 cases (male:19,709 and female: 10,664) of pulmonary tuberculosis patients born before 1 January 1957 and resided in Shanghai urban were followed up until 1986. The SMRs for lung cancer were 1. 38 and 2. 73 in males and females, respectively, both of which were statistically significant. When the risk was adjusted by smoking, the adjusted SMRs for lung cancer were 1.72 (95% CI: 1.11-2.53) in males and 2.79<95%CI:1.79-4.14) in females.The elevated risk of lung cancer among tuberculosis patients was irrelevant to smoking. INH treatment and X-ray exposure can not be explained for this higher risk.