rIL－2及sIL－2R单抗对晚期胃癌患者Tac受体表达的影响

EFFECTS OF rIL-2 AND sIL-2R MONOCLONE ANTIBODY ON TAC RECEPTOR FROM LATE GASTRIC CANCER PATIENTS

ｒＩＬ－２及ｓＩＬ－２Ｒ单抗对晚期胃癌患者Ｔａｃ受体表达的影响谬世雄，吴仲华，朱金水，徐家裕，王冠庭，徐文玉，王易上海第二医科大学附属瑞金医院内科（上海２０００２５）白细胞介素－２（ｉｎｔｅｒｌｅｕｋｉｎ－２，ＩＬ－２）是机体内一种重要免疫调节因子，...

By means of indirect fluorescent-immune assay, the expression of Tac receptor(TacR)on peripheral blood mononuclear cells from patients with late gastric cancer(n =120)and healthy persons(n=40) was measured. The effects of rIL-2 and sIL-2R monoclone antibody on TacR were observed at the same time. The following results were obtained :The abnormal expression of TacR was obvious and it was negatively correlated with serum sIL-2R levels,r =-0. 8167.If rIL-2 concentration was up to 25ng/ml, TacR expression reached its highest peak. If sIL-2R was more than 500U/ml, TacR was inhibited markedly. The changes of TacR were not obvious if sIL-2R monoclone antibody and rIL-2 were lower than 20U/ml and 5ng/ml respectively. On the other hand, after treated with rIL-2, the expression of TacR was improved and sIL-2R level was decreased; however, after chemotherapy the vice versa occurred.