摘要
本文作了福氏完全佐剂(Freund’scompleteadjuvant,FCA)包裹5-Fu的抗肿瘤作用的实验研究。在对小鼠S180肿瘤(腹水型),EAC肿瘤(腹水型)及H22肝癌(腹水型)荷瘤鼠的治疗实验中,一次性腹腔注射2mg~6mg的5-Fu(相当于70公斤人给予778~2334mg的剂量)均不能显著延长荷瘤鼠的存活期,盐水FCA亦无治疗作用,而5-FuFCA却显示出显著的治疗效果。4次实验,5-FU-FCA治疗组荷瘤鼠平均存活期30.6天~48.3天,均显著长于同次实验的各对照组,且每次实验都有2/8至3/8的荷瘤鼠可完全治愈。
FCA (Freund’s Complete Adjuvant, FCA)is usually used to entrap antigen toimmunize animal,We entrapped 5-Fu with FCA to slow their release in vivo and by means of this to reduce their side effects and to augment their antitumor effects.We called these FCA entrapped 5-Fu, 5-Fu-FCA. The results showed that: the average survival time of S180, EAC and H22 tumor bearing mice treated with 5-Fu was 18.3±1. 6, 17. 9±1. 9 and 19.1±3. 6 days respectively, none of them were cured,while that of 5-Fu-FCA treated groups was 48. 3±21. 1, 30. 6±2. 3 and 33.4±21. 6 days and 3/8,2/8, 2/8 of the tumor bearing mice cured respectively (vs 5-Fu treated groups, P<0. 0001).We conclude that: (1) the adverse effects of 5-Fu could be significantly reduced by means of FCA entrapping; (2)the antitumor effects of 5-Fu could be augmented by means of FCA entrapping.
出处
《肿瘤防治研究》
CAS
CSCD
北大核心
1995年第1期9-11,共3页
Cancer Research on Prevention and Treatment
关键词
氟脲嘧啶
福氏完全佐剂
抗肿瘤
实验研究
Fu (5-Fluorouracilum, 5-Fu)
FCA (Freund’s Complete Adjuvant, FCA)
Murine S180 sarcoma
Murine EAC carcinoma
Murine H22 hepato carcinoma