摘要
本实验采用敏感性较高的ＰＡＰ法检测了ＨＳＶ－２诱发的移植性小鼠宫颈癌和增生组织中的ＨＳＶ－２抗原。结果３０例ＨＳＶ－２诱发的增生或癌组织中有２４例阳性，阳性率达８０％。１４例经ＨＳＶ－２处理的非增生、非癌性宫颈组织中４例阳性，阳性率为２８．５７％。两组阳性率有显著性差异（Ｐ＜０．０１）。本实验在改良了传统的诱癌模型情况下，检测了ＨＳＶ－２抗原的表达并进一步确立了ＨＳＶ－２在实验性小鼠宫颈癌发生中的作用。
In this experiment,HSV-2 antigen in autoplastic cervical cancer and proliferated tissues of mice induced by HSV-2 virus were detected with highly sensitive PAP method.The results showed 24 cases,were positive in 30 proliferated or cancer tissues induced by HSV-2,which positive rate was 80%.However,in 14 non-proliferateod and non-cancer cervical tissues,only 4 cases were positive,positive rate was 28. 57 %.There were significant difference between positiue rates of the two group(P<0. 01).In modified model of induced cancer, the study investigated the expression of HSV-2 antigen and further verified that HSV-2. plays a certain role in experimental cervical cancer in mice.
出处
《肿瘤防治研究》
CAS
CSCD
北大核心
1995年第3期144-146,共3页
Cancer Research on Prevention and Treatment
