摘要
本文采用乳酸脱氢酶释放法测定了全反式维甲酸对二乙基亚硝胺诱导的鼠肝癌前状态自然杀伤细胞活性。结果表明二乙基亚硝胺诱癌１２周可明显导致大鼠ＮＫ细胞活性下降，而全反式维甲酸可预防二乙基亚硝胺的这种作用。因此，我们认为全反式维甲酸提高机体自然杀伤细胞活性可能为它预防肿瘤发生的机制之一。
Nature killer cell activity was detected in the liver precancerous condition of Wistar rat by lactate dehydrogenase (LOH) -release method, Significant decrease of NK activity was found in liver precancerous condition induced by diethylnitrosamine for 12 weeks, which was prevented by all trans-retinoic acid (RA). Therefore, we conclude that RA can enhance NK activity . which may be one of the important mechanisms for its chemoprevention of tumours
出处
《肿瘤防治研究》
CAS
CSCD
北大核心
1995年第4期195-196,共2页
Cancer Research on Prevention and Treatment
关键词
肝肿瘤
癌前状态
NK细胞
全反式维甲酸
Nature killer cell activity
Experimental hepatic carcinoma
All trans-retinoic Acid
Diethylnitrosamine
