LSA、HCG、β_2－MG及CEA联合检测对肺癌的诊断价值

Measurement of LSA, HCG, β_2-MG, CEA on Lung Neoplasma

本文检测了９４例术前肺癌和３４例术后肺癌血清ＬＳＡ、ＨＣＧ、β_２－ＭＧ和ＣＥＡ的变化。结果表明，肺癌患者这四项指标均较正常人明显升高，以腺癌最突出。术后较术前这四项指标均显著下降，而术后复发者ＨＣＧ、β_２－ＭＧ及ＣＥＡ均明显升高。Ⅰ到Ⅳ期肺癌各指标均逐渐升高。ＬＳＡ对肺癌诊断的敏感性和准确率最高，次为ＨＣＧ、β_２－ＭＧ。腺癌中ＬＳＡ、β_２－ＭＧ的血清水平、敏感性和准确率最高，鳞癌中ＬＳＡ和ＨＣＧ最高，ＳＣＬＣ中ＨＣＧ和β_２－ＭＧ最高。这四项指标的联合检测，有助于肺癌的诊断、鉴别诊断、病情分期及判断术后复发，值得临床深入研究。

Abstract Serum Lipid-bound Sialic Acid (LSA), Human Chorionic Gonadotropin (HCG), β2-Microglobulin (β2-MG) and Carcinoembronic Antigen (CEA) were measured in 94 preoperation and 34 postoperation of lung neoplasmas. The results showed that these four indexes were higher in lung cancer than those in normal controls, especially highest in adenocarcinoma, and they decreased in postoperation, but increased in turn from TermⅠto Term Ⅳ. The sensitivity and accurasy of LSA on diagnosis of lung cancer was superior to HCG and β2-MG. The serum level, sensitivity and accurasy of LSA were higher in adenocarcinoma, whereas LSA & HCG were higher in aquamous carcinoma,HCG & β2-MG were higher in Small Cell Lung Carcinoma (SCLC). Conbined measurement of these four indexes contributed to the diagnosis, differiation, and recurrence of postoperation.