摘要
本文就四氧嘧啶诱导糖尿病兔子早期（４周）与正常兔左心功能进行比较，发现糖尿病兔左室内压最大值（ｐｅａｋ），舒张末期内压（ＥＤＰ），等容收缩压（ＩＰ）、室内压波下降段最大速率（－Ｓｍａｘ），心力环（Ａｒｅａ）均显著小于正常对照组（ＩＰ、Ｓｍａｘ、Ｐ＜０．０５，Ａｒｅａ，Ｐ＜０．００５，ｐｅａｋ，Ｐ＜０．００２，ＥＤＰ，Ｐ＜０．００１）。本文结果显示糖尿病兔早期左室舒张及收缩功能均减退，可能与糖尿病代谢异常以及由此造成的心肌病变有关。
he early changes of cardiac function were studied in alloxan dialbetic rabbits in comparison with nomlal con-trols.After the onset of dialsetes for 4 weeks, left ventricular function indices including the peak pressure of leftventricule(Peak),the end diastolic pressure(EDP)the isovolumic contraction pressure(IP),the Peak negative -dp/dt max,(-Smax)and the area of lieart Working cycle(Area)were all significantly lower then those of normalcontirols(IP,-Smax,P < 0.005);Area(P< 0.05)EDP,P(<0.001)The results suggested that eraly decrease of leftventricular contraction and relaxation mdy be relaed to abnomal metabolism and diabetic cardiomyopathy.
出处
《重庆医科大学学报》
CAS
CSCD
1995年第4期268-271,共4页
Journal of Chongqing Medical University
关键词
四氧嘧啶
糖尿病兔
心功能
Alloxan
Diabetic rabbits
Cardiac function
